Custom Peptides
Cayman Chemical TopotecnhydrochlorIde 10mg
An inhibitor of DNA topoisomerase I and a derivative of camptothecin; inhibits DNA topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells (IC50s = 13 and 2 nM, respectively); induces cytotoxicity and DNA damage in HT-29 human colon adenocarcinoma cells (IC50s = 33 and 280 nM, respectively)
Cayman Chemical DIosArgtrIfluoroACTAte sa 10mg
A steroid-based cationic lipid; forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratio ≥4; facilitates transfection of plasmid DNA into H1299 and HeLa cells; has been used, coupled to DOPE, to bind siRNA and plasmid DNA to form cationic lipid nanoparticles for intracellular transport
Cayman Chemical C15 CeramIded18 115 0 10mg
A naturally occurring ceramide; has been found in L. nidifica and A. glomerata extracts, human erythrocytes, and the stratum corneum of P. domesticus
Cayman Chemical 1S 3R-RSL3 10mg
A ferroptosis inducer; inhibits GPX4 in a context-dependent manner; inhibits GPX4 in the presence of cell cytosol or recombinant human 14-3-3ε but does not inhibit recombinant human selenocysteine-containing GPX4 or purified rat testis GPX4, at 100 µM; inhibits peroxidase activity in GPX4-overexpressing COH-BR1 breast cancer cell lysates at 50 nM; inhibits TrxR1 (IC50 = 7.9 µM in a cell-free assay); selectively cytotoxic to H-RasV12-expressing BJeLR cells over wild-type Ras-expressing BJeH cells (EC50s = 0.01 and 2 µM, respectively); induces lipid peroxidation in Pfa1 fibroblasts at 100 nM; prevents tumor formation and inhibits tumor growth in BJeLR mouse xenograft models at 100 mg/kg
Cayman Chemical Rebaudioside M 10MG
A natural non-caloric sweetener and TAS1R2/TAS1R3 agonist; increases intracellular calcium levels in HEK293 cells expressing human TAS1R2 and TAS1R3 (EC50 = 29.54 µM); has a relative sweetness potency 200-350 times that of sucrose; metabolized by gut microbiota to steviol
Cayman Chemical PPTNhydrochlorIde 10mg
A P2Y14 receptor antagonist; inhibits forskolin-induced cyclic AMP accumulation in C6 cells expressing human P2Y14 (EC50 = ~10 nM) but not CHO cells expressing P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 at 1 µM; inhibits UDP-glucose-induced IL-1β and CCL2 secretion, as well as ERK, JNK, and p38 MAPK phosphorylation in isolated rat SGCs at 5 µM; trigeminal administration reduces CFA-induced mechanical hyperalgesia in rats at 5 and 10 µM
Cayman Chemical 2-AcetylacteosIde 10mg
A phenylethanoid glycoside; selectively inhibits aldose reductase over maltase and sucrase (IC50s = 0.071, >300, and 277 µM, respectively, for the rat enzymes); scavenges superoxide radicals in a cell-free assay and inhibits AAPH-induced hemolysis in isolated rat red blood cells; decreases glutamate-induced cytotoxicity in primary rat cortical neurons at 0.1, 1, and 10 µM; protects primary mouse hepatocytes against D-galactosamine-induced cytotoxicity (IC50 = 4.8 UG/ml); prevents decreases in bone strength in ovariectomized mice from 10-40 mg/kg
Cayman Chemical Seralutinib 10MG
A PDGFR, c-Kit, and CSF1R inhibitor; inhibits PDGF-BB-induced phosphorylation of ERK in H1703 cells, HPASMCs, and HLFs (IC50s = 74, 49, and 62 nM, respectively); inhibits stem cell factor-induced c-Kit autophosphorylation in HPAECs and M-CSF-induced CSF1R phosphorylation in human primary differentiated macrophages (IC50s = 7.8 and 14.4 nM, respectively); inhibits the proliferation of H1703 cells and PDGF-BB-induced HPASMCs and HLFs (IC50s = 32, 33, and 29 nM, respectively); prevents increases in pulmonary artery systolic pressure in a rat model of pulmonary arterial hypertension induced by monocrotaline pneumonectomy when administered via passive inhalation at 2.5 mg/kg
Cayman Chemical PapRIVtrIfluoROCTAte salt 10mg
A quorum-sensing peptide; induces IL-6 and TNF-α production by, and NF-κB translocation in, BV-2 microglia cells from 1-25 µM
Cayman Chemical BRITE338733 10mg
A RecA inhibitor (IC50 = 4.7 µM for ATP hydrolysis in a cell-free assay)
Cayman Chemical WaTx36-68scorpIontrIf 10mg
A cell-penetrating peptide and TRPA1 activator; selectively induces currents in HEK293T cells expressing human TRPA1 (EC50 = 15 nM) over cells expressing human TRPM8 or TRPV1 at 100 nM or rat Kv1.2, Kv2.1, Kv3.1, or Kv4.3 at 1,000 nM; induces nocifensive behavior in wild-type but not Trpa1-/- mice
Cayman Chemical IndolImIn-214 10mg
A genotoxic gut microbiota metabolite; increases γH2AX levels in HeLa cells at 25 and 100 UG/ml; increases the tail DNA percentage in a comet assay using HeLa cells at 100 UG/ml
Cayman Chemical HCKFWWtrIfluoROCTAte salt 10mg
A thiol-containing peptide; has been used as an analyte in the development of zirconium nanoparticles as probes and matrices for mass spectrometry applications